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2009), doctors must be clear on the ethical basis of this judgement.The argument in favour of the removal of life support states that to continue thistreatment puts the patient through unnecessary suffering with no clear positive out-come, thus contravening non-male?cence and bene?cence, respectively. Topiramate appears tobe efficacious at doses lower than those used to treat ap-proved conditions, with studies suggesting benefi t below100 mg/day (Gatto et al., 2003; Ondo et al., 2006). Clinical practice guidelines for the management of candidiasis:2009 update by the Infectious Diseases Society of America. Rabbani B, Mahdieh N, Hosomichi K, Nakaoka H, Inoue I (2012) Next-generation sequenc-ing: impact of exome sequencing in characterizing Mendelian disorders.

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